Location History:
- Nerima-ku, JP (2009)
- Tokyo, JP (2015 - 2016)
Company Filing History:
1 out of 575 
1 out of 109 
1 out of 1 Years Active: 2009-2016
Title: Makoto Makishima: Innovator in Vitamin D Receptor Modulation
Introduction
Makoto Makishima is a prominent inventor based in Tokyo, Japan. He has made significant contributions to the field of vitamin D receptor modulation, holding a total of 3 patents. His work focuses on developing compounds that selectively interact with vitamin D receptors, aiming to minimize adverse effects while maximizing therapeutic benefits.
Latest Patents
One of his latest patents is titled "Function-selective vitamin D receptor agonist." This invention provides a VDR ligand that does not induce hypercalcemia, a common adverse reaction associated with vitamin D3 preparations. Additionally, he has developed a composition that includes lithocholic acid propionate, its salts, solvates, or prodrugs. Another notable patent is "Vitamin D receptor modulators with partial agonist activity." This invention presents a compound that acts as a selective vitamin D receptor modulator, ensuring action-selectivity or tissue-selectivity without causing hypercalcemia while delivering other beneficial effects.
Career Highlights
Throughout his career, Makoto Makishima has worked with notable companies, including Ono Pharmaceutical Co., Ltd. His innovative research has positioned him as a key figure in the pharmaceutical industry, particularly in the development of vitamin D-related therapies.
Collaborations
Makoto has collaborated with esteemed colleagues such as Sachiko Yamada and Yuji Matsuzawa. Their combined expertise has contributed to advancing research in vitamin D receptor modulation.
Conclusion
Makoto Makishima's contributions to the field of vitamin D receptor modulation highlight his innovative spirit and dedication to improving health outcomes. His patents reflect a commitment to developing safer and more effective therapeutic options.