This inventor holds 2 USPTO granted patents. Top assignee: The United States of America, as Represented by the Secretary, Department of Health and Human Services. Active years: 2001-2006.
Company Filing History:
Years Active: 2001-2006
Title: Mae Jean Miller: Innovator in Adrenomedullin Research
Introduction
Mae Jean Miller is a distinguished inventor based in Monrovia, MD (US). She has made significant contributions to the field of human pathology and physiology through her innovative research. With a total of 2 patents, her work focuses on the functional role of adrenomedullin (AM) and its implications in cancer and insulin secretion.
Latest Patents
Mae Jean Miller's latest patents include groundbreaking research on the functional role of adrenomedullin (AM) in human pathology and physiology. The methods of her invention demonstrate that adrenomedullin is expressed in human cancer cell lines of diverse origin and functions as a universal autocrine growth factor driving neoplastic proliferation. Her patents provide AM peptides and AM antibodies that are useful in therapeutic, pharmacologic, and physiologic compositions. Additionally, her work outlines methods for the diagnosis, treatment, and prevention of diseases utilizing these compositions. The experimental models she developed have shown that AM inhibits insulin secretion in a dose-dependent manner. Notably, the monoclonal antibody MoAb-G6, which neutralizes AM bioactivity, was shown to increase insulin release fivefold, an effect that was reversed by the addition of synthetic AM.
Career Highlights
Mae Jean Miller is affiliated with the National Institutes of Health, a component of the US Department of Health & Human Services. Her research has garnered attention for its potential applications in therapeutic settings, particularly in cancer treatment and metabolic disorders.
Collaborations
Some of her notable coworkers include Alfredo Martinez and Edward J Unsworth, who have contributed to her research endeavors.
Conclusion
Mae Jean Miller's innovative work in the field of adrenomedullin research highlights her significant contributions to understanding human pathology and physiology. Her patents pave the way for advancements in therapeutic applications and disease prevention.