Company Filing History:
Years Active: 2021
Title: Maciej E Domaradzki: Innovator in Biological Synthesis
Introduction
Maciej E Domaradzki is a notable inventor based in Glendale, NJ (US). He has made significant contributions to the field of biological synthesis, particularly in the production of apocarotenoids. His innovative work has led to the development of a patented process that enhances the synthesis of valuable compounds.
Latest Patents
Domaradzki holds a patent for the "Production of alpha-(R)-(E)-(+)-ionone in recombinant." This invention provides an improved biological synthesis of the apocarotenoid α-ionone. The final native step involved in the natural apocarotenoid pathway depends on an endogenous farnesyl pyrophosphate synthase (FPPs). From there, heterologous geranylgeranyl pyrophosphate synthase (crtE), phytoene synthase (crtB), phytoene desaturase (crtI), lycopene ε-cyclase (LycE), and a Carotenoid Cleavage Dioxygenase (CCD1) are required to complete the synthesis of α-ionone. Lycopene ε-cyclase from lettuce or modified cyclase was used to overproduce lycopene, which was then cleaved by the carotenoid cleavage dioxygenase from Ph-CCD1.
Career Highlights
Domaradzki is currently associated with Centrome, Inc., where he continues to advance his research and development efforts. His work has been instrumental in enhancing the understanding and production of important biological compounds.
Collaborations
One of his notable coworkers is Francisco Javier Saitua Perez. Their collaboration has contributed to the innovative research environment at Centrome, Inc.
Conclusion
Maciej E Domaradzki is a prominent figure in the field of biological synthesis, with a focus on the production of α-ionone. His patented work and ongoing contributions continue to impact the scientific community positively.