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Title: Innovations of Luciano Polonelli in Glucan-Based Vaccines
Introduction
Luciano Polonelli is a notable inventor based in Parma, Italy. He has made significant contributions to the field of immunology, particularly through his innovative work on glucan-based vaccines. With a total of five patents to his name, Polonelli's research focuses on developing protective immunogenic compositions that can combat systemic fungal infections.
Latest Patents
One of Polonelli's latest patents involves the creation of glucan-based vaccines. These vaccines utilize anti-glucan antibodies, which have been found to be protective against systemic fungal infections. However, the protective efficacy of these antibodies can be inhibited by blocking antibodies. The invention provides an immunogenic composition that includes a glucan and a pharmaceutically acceptable carrier. When administered to a mammalian recipient, this composition elicits protective anti-glucan antibodies without triggering antibodies that inhibit their efficacy. The glucan can be presented on the surface of a protease-treated microbial cell or as a protein-glucan conjugate. Additionally, the glucan may be substituted by a glucan mimotope, a peptidomimetic of a glucan mimotope, or nucleic acid encoding a mimotope. The anti-glucan antibodies demonstrate broad-spectrum microbicidal activity, with β-glucans being preferred, particularly those containing one or more β-1,6 linkages.
Career Highlights
Throughout his career, Polonelli has worked with various companies, including Chiron S.r.l. His innovative research has led to advancements in vaccine development, particularly in the area of fungal infections. His work is characterized by a commitment to improving immunological responses through novel compositions.
Collaborations
Polonelli has collaborated with notable colleagues such as Antonio Cassone and Giuseppe Teti. These collaborations have further enriched his research and contributed to the development of effective immunogenic solutions.
Conclusion
Luciano Polonelli's contributions to the field of immunology, particularly through his glucan-based vaccines, highlight his innovative spirit and dedication to advancing medical science. His work continues to pave the way for new treatments against systemic fungal infections.