Company Filing History:
Years Active: 2004-2009
Title: Lucetta Caston: Innovator in Adenoviral Vector Production
Introduction
Lucetta Caston is a notable inventor based in Limerick, PA (US), recognized for her contributions to the field of viral vector production. With a total of three patents to her name, she has made significant advancements in the methods used for producing purified adenoviral vectors. Her work addresses critical challenges in the efficiency and quality of viral vector yields.
Latest Patents
Lucetta Caston's latest patents include innovative methods for producing purified adenoviral vectors. The first patent focuses on improving yields of viral vectors when grown in cell culture systems. It highlights the effectiveness of low-medium perfusion rates in attached cell culture systems, which have been shown to enhance yields. Additionally, her research indicates that improved Ad-p53 production can be achieved with cells grown in serum-free conditions, particularly in serum-free suspension culture. The use of detergent lysis is also emphasized as a crucial factor in increasing yields. This combination of techniques allows for the purification of the virus through a single chromatography step, resulting in purified virus of comparable quality to those prepared using double CsCl banding with ultracentrifugation.
Another patent by Caston also addresses the production and purification of adenoviral vectors, reiterating the importance of the same methodologies for enhancing yields in cell culture systems.
Career Highlights
Throughout her career, Lucetta Caston has worked with prominent companies in the biotechnology sector, including Introgen Therapeutics Inc. and Introgen Therapeutics, Inc. Her experience in these organizations has contributed to her expertise in viral vector production and purification.
Collaborations
Lucetta has collaborated with notable colleagues such as Shuyuan Zhang and Capucine Thwin, who have contributed to her research endeavors in the field of adenoviral vectors.
Conclusion
Lucetta Caston's innovative work in the production and purification of adenoviral vectors has made a significant impact in the biotechnology industry. Her patents reflect her commitment to improving viral vector yields and quality, showcasing her role as a leading inventor in this critical area of research.