Lowell J Underwood

Title: Innovations of Lowell J. Underwood: The CA125 Gene and Its Therapeutic Potential

Introduction

Lowell J. Underwood, an accomplished inventor based in Little Rock, Arkansas, has made significant contributions to the field of biomedical research. With a remarkable portfolio of 20 patents, Underwood focuses on innovations that have the potential to enhance diagnostic and therapeutic interventions.

Latest Patents

Among his latest advancements is the patented work on the CA125 gene. Underwood's research involves the cloning of the CA125 gene, unveiling multiple repeat sequences and the identification of its carboxy terminus. The CA125 molecule features three primary domains: an extracellular amino terminal domain (Domain 1), a large multiple repeat domain (Domain 2), and a carboxy terminal domain (Domain 3) which incorporates a transmembrane anchor and a short cytoplasmic domain. The amino terminal domain is characterized by its capacity for O-glycosylation and is rich in serine and threonine residues. Notably, Underwood's innovation has led to the elucidation of a CA125 cDNA sequence that can be transcribed or expressed within animal or human cells, thereby enhancing its potential applications in clinical settings. The repeat domain consists of 156 amino acid repeat units, with over 60 units identified and sequenced, highlighting significant structural intricacies related to disulfide bridged C-enclosures.

Career Highlights

During his time at the University of Arkansas, Underwood has exhibited a dedication to advancing scientific knowledge and technology. His extensive research endeavors have contributed to groundbreaking discoveries in the realm of genetic diagnostics and treatments.

Collaborations

Underwood has had the privilege of collaborating with esteemed colleagues such as Timothy J. O'Brien and John Beard, further fostering innovation and research excellence. Through these partnerships, he has amplified the impact of his work, leading to collective advancements in the understanding of the CA125 molecule and its implications in medical science.

Conclusion

Lowell J. Underwood stands out as a prominent inventor whose work on the CA125 gene continues to influence the fields of diagnostics and therapy. His dedication to research and collaboration at the University of Arkansas sets the stage for further innovations that may significantly restore and improve patient health outcomes. The insights derived from his patents promise to pave the way for new developments in biomedical applications and reinforce the importance of genetic research in modern medicine.