Company Filing History:
Years Active: 2004-2008
Title: Innovations by Louise M Bilezikjian
Introduction
Louise M Bilezikjian is a notable inventor based in San Diego, California. She has made significant contributions to the field of biochemistry, particularly in the study of protein hormones. With a total of two patents to her name, her work has implications for understanding hormonal regulation.
Latest Patents
Her latest patents include a method of inhibiting the formation of inhibin/betaglycan complexes with an anti-betaglycan antibody. Inhibins and activins are protein hormones that modulate various regulatory pathways. Competitive binding experiments have shown that betaglycan, the type III TGF-β receptor, also functions as an inhibin receptor. By augmenting the binding of inhibin to the ActRII activin receptor, betaglycan effectively sequesters ActRII away from activin, thereby reducing activin signaling. This complex may generate novel signals distinct from those initiated by activin signaling via ActRII and ALK4. Betaglycan is produced in specific nuclei of the rat brain and by certain cell types within the adult rat pituitary, testis, and ovary. The presence of betaglycan in inhibin-responsive tissues suggests its role as an inhibin-specific receptor mediating inhibin responses.
Career Highlights
Louise M Bilezikjian has been associated with the Research Development Foundation, where she has furthered her research and innovation in the field. Her work has been instrumental in advancing the understanding of hormonal interactions and their implications in various biological processes.
Collaborations
Some of her notable coworkers include Wylie Walker Vale, Jr. and Kathy A Lewis. Their collaborative efforts have contributed to the advancements in the research surrounding inhibins and activins.
Conclusion
Louise M Bilezikjian's contributions to the field of biochemistry through her patents and research have significantly enhanced the understanding of hormonal regulation. Her work continues to influence the scientific community and pave the way for future innovations.