Louis B Hoff

Title: Innovations of Louis B Hoff

Introduction

Louis B Hoff is a notable inventor based in Belmont, CA, with a remarkable portfolio of seven patents. His work primarily focuses on advancements in biological analysis and optical technologies. Hoff's contributions have significantly impacted the fields of microarray analysis and illumination systems.

Latest Patents

Among his latest patents is the "Multiaxis focusing mechanism for microarray analysis." This invention outlines systems and methods for positioning a multi-featured biological array relative to a signal acquisition device. The detection of the array's positional deviation is achieved through a calibration beam reflected from the array surface, which is then detected by a position-sensitive detector (PSD). The PSD-measured positional deviation can be transformed and utilized in a control loop to correct for positional variations of the array. Additionally, the calibration beam and PSD can detect the array or feature boundaries, allowing for lateral centering or positioning of the array relative to the signal acquisition device.

Another significant patent is the "Shaped illumination geometry and intensity using a diffractive optical element." This invention describes a method and apparatus designed to illuminate a target effectively. The apparatus includes a first lens that receives light from a light source, a diffractive optical element that regulates the light from the first lens, and a second lens that directs the regulated light onto a selected area of the target.

Career Highlights

Hoff has had a distinguished career, working with prominent companies such as PerkinElmer Corporation and its Applied Biosystems Division. His experience in these organizations has allowed him to develop and refine his innovative ideas, contributing to advancements in scientific research and technology.

Collaborations

Throughout his career, Hoff has collaborated with notable colleagues, including Mark F Oldham and John A Bridgham. These partnerships have fostered a creative environment that has led to significant technological advancements.

Conclusion

Louis B Hoff's innovative contributions to the fields of microarray analysis and optical technologies demonstrate his commitment to advancing scientific research. His patents reflect a deep understanding of complex systems and a dedication to improving methodologies in biological analysis.