Company Filing History:
Years Active: 2018
Title: The Innovations of Loren Michel
Introduction
Loren Michel is an accomplished inventor based in Clayton, MO (US). He has made significant contributions to the field of medical imaging through his innovative work on radiolabeled tracers. His research focuses on enhancing the capabilities of positron emission tomography (PET) imaging, particularly in relation to cancer diagnostics.
Latest Patents
Loren Michel holds a patent for "Radiolabeled tracers for poly (ADP-ribose) polymerase-1 (PARP-1), methods and uses therefor." This patent discloses PARP-1 inhibitors that can be fluorine-18 labeled for use as tracers in PET imaging. Among the compounds synthesized, 2-[p-(2-Fluoroethoxy)phenyl]-1.3.10-triazatricyclo[6.4.1.0]trideca-2,4(13),5,7-tetraen-9-one (12) exhibited the highest inhibition potency for PARP-1 with an IC of 6.3 nM. The synthesis of [F]-12 is achieved under conventional conditions, yielding a high specific activity with a decay-corrected yield of 40-50%. MicroPET imaging using [F]-12 in MDA-MB-436 tumor-bearing mice demonstrated significant accumulation of [F]-12 in tumors, with binding that can be blocked by olaparib. These compounds have substantial utility for tumor imaging.
Career Highlights
Loren Michel is affiliated with Washington University, where he continues to advance his research in medical imaging and cancer diagnostics. His work has garnered attention for its potential impact on improving diagnostic techniques and treatment planning for cancer patients.
Collaborations
Loren collaborates with esteemed colleagues such as Robert H Mach and Wenhua Chu, contributing to a dynamic research environment that fosters innovation and discovery.
Conclusion
Loren Michel's contributions to the field of medical imaging through his innovative patents and research collaborations highlight his role as a significant inventor in the realm of cancer diagnostics. His work continues to pave the way for advancements in PET imaging technology.