Liyun Ke

Title: Liyun Ke: Innovator in Milbemycin Production

Introduction

Liyun Ke is a notable inventor based in Hubei, China. He has made significant contributions to the field of pharmaceutical production, particularly in the development of high-yield strains for milbemycin. His innovative approach has led to advancements that benefit both the industry and market demands.

Latest Patents

Liyun Ke holds a patent for a milbemycin strain with high-yield and its application. The patent describes a strain for high-yield production of milbemycin, specifically detailing the original strain MI-W1-2017001, which underwent mutation breeding using an atmospheric and room temperature plasma mutation method. This process resulted in the creation of a high-yield strain, HZMRYB-5. The fermentation level of this new strain is improved by approximately 70% compared to the original strain. Furthermore, through optimization of the fermentation process and formulation, the fermentation level is enhanced by an additional 35%. This innovation significantly reduces the fermentation cost of the product while meeting industrial fermentation requirements. The optimized fermentation process achieves a nearly 3:7 ratio of A3 and A4 in the fermentation liquid through mixed fermentation of strains MI-W1-2017001 and HZMRYB-5, effectively addressing market demands and streamlining the process steps of separation, purification, and mixing.

Career Highlights

Liyun Ke is currently associated with Hubei Honch Pharmaceutical Co., Ltd. His work at the company focuses on enhancing the production efficiency of pharmaceutical compounds, particularly through innovative fermentation techniques. His contributions have positioned him as a key figure in the pharmaceutical industry.

Collaborations

Liyun Ke collaborates with notable colleagues, including Renwen Zhang and Wenkai Zhang. Their teamwork fosters an environment of innovation and shared expertise, further advancing their projects in pharmaceutical development.

Conclusion

Liyun Ke's innovative work in the field of milbemycin production exemplifies the impact of scientific advancements on the pharmaceutical industry. His patented strain and optimized processes not only enhance production efficiency but also meet the growing market demands.