Lingjun Li

Title: Innovations of Inventor Lingjun Li

Introduction

Lingjun Li is a prominent inventor based in San Diego, California. He has made significant contributions to the field of nucleic acid research, holding three patents that showcase his innovative approaches. His work primarily focuses on the incorporation of unnatural nucleotides, which has implications for various applications in biotechnology and molecular biology.

Latest Patents

One of Lingjun Li's latest patents is titled "Method for the site-specific enzymatic labelling of nucleic acids in vitro by incorporation of unnatural nucleotides." This patent describes analogs of unnatural nucleotides that feature predominantly hydrophobic nucleobase analogs. These analogs are capable of forming unnatural base pairs during DNA polymerase-mediated replication or RNA polymerase-mediated transcription. The introduction of these unnatural nucleobases into oligonucleotides allows for site-specific cleavage and the potential for functionalization with cargo-bearing reagents through various chemical reactions.

Career Highlights

Throughout his career, Lingjun Li has worked with esteemed organizations such as The Scripps Research Institute and the U.S. Government's National Institutes of Health Division of Extramural Inventions and Technology Resources. His work in these institutions has furthered the understanding and application of nucleic acid technologies.

Collaborations

Lingjun Li has collaborated with notable scientists, including Floyd E. Romesberg and Denis A. Malyshev. These collaborations have contributed to the advancement of research in the field of unnatural nucleotides and their applications.

Conclusion

Lingjun Li's innovative work in the field of nucleic acids has led to significant advancements in biotechnology. His patents reflect a deep understanding of molecular mechanisms and open new avenues for research and application.