Linda Hseih-Wilson

Title: Linda Hseih-Wilson: Advancing Protein Glycosylation Detection.

Introduction

Linda Hseih-Wilson is an inventor associated with the California Institute of Technology in San Marino, California. Her patent work addresses methods for detecting post-translationally modified proteins, particularly proteins with glycosylation.

Latest Patents

The supplied information identifies one patent associated with Hseih-Wilson: “Method and Compositions for the Detection of Protein Glycosylation.” The invention describes a rapid, sensitive approach for detecting modified proteins, including O-GlcNAc modifications that may be difficult to identify with other techniques. In one embodiment, an engineered mutant of β-1,4-galactosyltransferase transfers an unnatural ketone functionality onto O-GlcNAc-glycosylated proteins. The ketone then provides a site for attaching biotin, enabling detection and visualization of proteins present at levels near the limits of traditional methods. The patent also describes potential applications in detecting disease states, including cancer, Alzheimer’s disease, neurodegeneration, cardiovascular disease, and diabetes. The supplied record lists 1 patent.

Career Highlights

Hseih-Wilson’s listed invention applies biochemical engineering to improve the detection of protein modifications. By providing a chemical handle for labeling glycosylated proteins, the method offers researchers a way to study proteins that might otherwise remain undetected.

Collaborations

The supplied information names Hwan-Ching Tai and Sabine Arndt as coworkers. Their inclusion points to a collaborative research context connected with the work described in the patent.

Conclusion

Linda Hseih-Wilson’s patent describes a sensitive method for detecting protein glycosylation, with potential value in biological research and the investigation of several diseases.