Company Filing History:
Years Active: 2023-2024
Title: Innovations in Sperm DNA Fragmentation Detection by Li-Sheng Chang
Introduction
Li-Sheng Chang, an esteemed inventor based in Taichung, Taiwan, has made significant contributions to the field of reproductive health through his innovative work. With a total of two patents, he focuses on advancing methods for detecting sperm DNA fragmentation, which is crucial for understanding male fertility.
Latest Patents
Li-Sheng Chang's most recent patents revolve around methodologies and kits designed for detecting sperm DNA fragmentation in semen samples. These methods detail the process of embedding sperm cells in a gel, denaturing their DNA, and lysing the nuclear proteins of the sperm cells. Notably, his approach incorporates the use of sodium dodecyl sulfate (SDS) and the chaotropic agent urea in the lysis solution, effectively releasing DNA from protamines, which significantly reduces the lysis time. The comprehensive methods and accompanying kits provided by Chang are invaluable for diagnostic purposes in fertility treatments.
Career Highlights
Currently, Li-Sheng Chang is affiliated with Bonraybio Co., Ltd., a company recognized for its commitment to developing innovative solutions in biomedical technology. His continuous research and development initiatives align with the company’s mission to enhance diagnostic capabilities in medical laboratories.
Collaborations
Chang collaborates with notable colleagues, including Cheng-Teng Hsu and Hsiu-Chin Lee, who also contribute to the research landscape in reproductive health. Their collective efforts emphasize teamwork and innovation in addressing the challenges associated with male fertility.
Conclusion
Li-Sheng Chang stands out as a prominent inventor in the realm of reproductive health, particularly through his cutting-edge patents addressing sperm DNA fragmentation detection. His work at Bonraybio Co., Ltd. and collaboration with skilled professionals highlight the importance of innovation in improving diagnostic methodologies and, ultimately, enhancing fertility treatments for couples facing reproductive challenges.