Li-ming Yuan

Title: Innovations by Li-ming Yuan in Drug Resistance Research

Introduction

Li-ming Yuan is an accomplished inventor based in Flushing, NY (US). He has made significant contributions to the field of drug resistance through his innovative research and patents. His work focuses on understanding the genetic factors that contribute to multiple drug resistance in cells.

Latest Patents

Li-ming Yuan holds a patent for the "Identification of differentially methylated multiple drug resistance loci." This invention provides genomic loci that are hypermethylated and differentially expressed in drug-resistant cells compared to non-drug-resistant cells. The genomic loci identified in this patent are homologous to the rab6 locus but map to a different chromosomal position. The invention also includes nucleic acids isolated from these genomic loci using Methyl-Differential Display (MDD) methods, which encompass genomic DNAs and cDNAs. These nucleic acids serve as valuable probes for detecting mutations and methylation patterns, as well as for measuring the expression of mRNA from the identified genes.

Career Highlights

Li-ming Yuan is affiliated with the North Shore-Long Island Jewish Research Institute, where he continues to advance his research in drug resistance. His work has implications for therapeutic treatments, particularly in identifying and inhibiting multiple drug resistance.

Collaborations

Li-ming Yuan collaborates with notable colleagues, including Hao-Peng Xu Duffy and Ji-dong Shan, who contribute to his research endeavors.

Conclusion

Li-ming Yuan's innovative work in identifying genomic loci related to drug resistance highlights the importance of genetic research in developing effective treatments. His contributions are paving the way for advancements in understanding and combating drug resistance in various medical contexts.