The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 07, 2006
Filed:
Nov. 18, 1999
Hao-peng Xu Duffy, Centerport, NY (US);
Ji-dong Shan, Flushing, NY (US);
Li-ming Yuan, Flushing, NY (US);
Daniel Budman, Locust Valley, NY (US);
Anthony Calabro, Bethpage, NY (US);
Hao-Peng Xu Duffy, Centerport, NY (US);
Ji-dong Shan, Flushing, NY (US);
Li-ming Yuan, Flushing, NY (US);
Daniel Budman, Locust Valley, NY (US);
Anthony Calabro, Bethpage, NY (US);
North Shore - Long Island Jewish Research Institute, Manhasset, NY (US);
Abstract
The present invention provides genomic loci which are hypermethylated and differentially expressed in drug resistant cells compared to non-drug resistant cells. These genomic loci are homologous to the rab6 locus but map to a different chromosomal position. The present invention also provides nucleic acids isolated from these genomic loci by Methyl-Differential Display (MDD) methods, including genomic DNAs and cDNAs. The present nucleic acids are useful as probes for detecting mutations and the methylation patterns of the newly identified genomic loci, and of homologous nucleic acids. Nucleic acids of the present invention are also useful for detecting expression of mRNA from herein identified genes, for measuring expression of those and homologous genes sequences, and for determining suitability of therapeutic treatment. The disclosed nucleic acids and their homologs are useful for inhibition of multiple drug resistance. Cells are disclosed which are useful for identification or modulators of multidrug resistance.