This inventor holds 4 USPTO granted patents and 4 published patent applications and 1 EPO patent. Top assignees: Laboratoire Francais Du Fractionnement Et Des Biotechnologies, Genzyme Transgenics Corporation, Gtc Biotherapeutics, Inc.. Active years: 2003-2019.
Company Filing History:
2 out of 97 
1 out of 12 
1 out of 11 Years Active: 2003-2019
Title: The Innovative Journey of Li-How Chen in Biotechnology
Introduction
Li-How Chen, an accomplished inventor based in Acton, Massachusetts, has made significant contributions to the field of biotechnology. With a remarkable portfolio of four patents, his work primarily focuses on advanced therapeutic antibodies and protein modifications, addressing critical medical challenges.
Latest Patents
Among his latest innovations, Chen has developed patents for "Highly Galactosylated Anti-TNF-alpha Antibodies and Uses Thereof." This patent covers compositions that relate to populations of anti-TNF-alpha antibodies exhibiting a high level of galactosylation. Furthermore, he has disclosed methods for the production and application of these specific antibodies, including the notable adalimumab. Another significant patent focuses on "Proteins with Modified Glycosylation and Methods of Production Thereof," which includes claims for transgenic animals and cells used to create proteins with altered glycosylation, particularly emphasizing increased sialylation.
Career Highlights
Throughout his career, Li-How Chen has served in prominent roles at various biotechnology companies, including Laboratoire Français Du Fractionnement Et Des Biotechnologies and Genzyme Transgenics Corporation. His expertise in protein engineering and antibody therapeutics has positioned him as a key player in the advancements of biopharmaceutical technologies.
Collaborations
Chen has collaborated with notable figures in the industry, such as Harry M. Meade and Paul DiTullio. These partnerships have allowed for the exchange of innovative ideas and methodologies, further enhancing the development of groundbreaking biotechnological solutions.
Conclusion
Li-How Chen's contributions to biotechnology through his patents and collaborations underline the importance of innovation in medical therapeutics. His focus on enhancing antibody performance and protein modifications has the potential to pave the way for new treatments and better patient outcomes. As the field continues to evolve, inventors like Chen are at the forefront, driving progress and inspiring future inventions.