Company Filing History:
5 out of 28 
3 out of 35 
2 out of 51 
Years Active: 1989-2010
Title: Leslie M. Hoffman: Innovator in Plasmid Control Technologies
Introduction: Leslie M. Hoffman, an accomplished inventor based in Madison, WI, has significantly contributed to the field of biotechnology with her innovative work related to plasmid control. With a portfolio that includes 10 patents, Leslie's expertise lies in developing methods and compositions for managing the replication processes within host cells, which are crucial for various applications in genetic research.
Latest Patents: Among her notable recent patents are two groundbreaking inventions. The first patent, titled "Compositions and methods for controlling copy number for a broad range of plasmids and uses thereof," describes innovative compositions and methods that enable the conditional control of plasmid copy numbers in host cells. This method includes a host cell comprised of a poly(A) polymerase gene operably linked to a conditionally inducible promoter, facilitating the stable maintenance of heterologous DNA sequences.
The second patent, "Methods and compositions for amplifying DNA clone copy number," focuses on retrofitting DNA within low-copy vectors, such as fosmids or BACs. This method utilizes an artificial transposon that introduces a conditional multi-copy origin of replication into the vector's DNA. This sophisticated approach allows the replication to be regulated, ensuring increased synthesis of clone DNA only in the presence of an inducer.
Career Highlights: Throughout her career, Leslie has been associated with renowned organizations such as Epicentre Technologies Corporation and Lubrizol Genetics, Inc. These roles have allowed her to apply her innovative ideas in real-world applications, furthering the potential of genetic engineering and biotechnology.
Collaborations: Leslie's collaborative efforts have also been noteworthy. She has worked alongside esteemed colleagues such as Jerome J. Jendrisak and Darin J. Haskins, contributing to advancements in the field of genetic research. These collaborations have fostered an environment where creative solutions and scientific inquiries thrive, leading to significant discoveries.
Conclusion: Leslie M. Hoffman exemplifies the spirit of innovation in the biotechnology sector. Her work on plasmid control and DNA amplification showcases her commitment to advancing genetic research through her patented inventions. As she continues to explore new frontiers in her field, Leslie remains a pivotal figure in the ongoing evolution of biotechnology.