Lesley A MacKin

Title: Lesley A MacKin: Innovator in Pharmaceutical Science

Introduction

Lesley A MacKin is a notable inventor based in Evanston, IL (US), recognized for her contributions to pharmaceutical science. She holds 2 patents that focus on enhancing the bioavailability of the selective cyclooxygenase-2 inhibitory drug, celecoxib. Her innovative work has significant implications for the treatment of various medical conditions.

Latest Patents

MacKin's latest patents include a solid-state form of celecoxib that is presented in an amorphous form. This formulation aims to improve the drug's bioavailability. The patent details a celecoxib drug substance where celecoxib is detectable as amorphous celecoxib. Additionally, it describes a celecoxib-crystallization inhibitor composite that includes particles of amorphous celecoxib in association with one or more crystallization inhibitors, such as polymers. The patent also outlines a pharmaceutical composition that incorporates this composite along with various excipients. Furthermore, it provides processes for preparing amorphous celecoxib and methods for treating medical conditions where cyclooxygenase-2 inhibitors are indicated.

Career Highlights

Throughout her career, Lesley A MacKin has worked with prominent organizations, including Pharmacia Corporation and Pfizer, Inc. Her experience in these companies has contributed to her expertise in pharmaceutical innovations.

Collaborations

MacKin has collaborated with notable colleagues, including Michael J Hageman and Xiaorong He, which has further enriched her research and development efforts.

Conclusion

Lesley A MacKin's work in the field of pharmaceutical science, particularly her patents related to celecoxib, showcases her innovative spirit and dedication to improving medical treatments. Her contributions continue to influence the pharmaceutical industry positively.