Leopold Flohe'

Title: The Innovations of Leopold Flohe'

Introduction

Leopold Flohe' is a notable inventor based in Roetgen, Germany. He has made significant contributions to the field of biotechnology, particularly in the development of plasmids for protein expression. His work has implications for therapeutic applications, showcasing the intersection of science and innovation.

Latest Patents

Leopold Flohe' holds a patent for "Plasmids, their construction and their use in the manufacture of a." This patent describes plasmids containing synthetic DNA sequences that are suitable for the expression of the intermediate protein of the recombinant scu-PA. The plasmids are designed for use in Enterobacteriaceae, especially in E. coli, achieving expression rates far superior to those of prior methods. The patent details the construction of these plasmids, which include operons with a regulatable promoter, a Shine-Dalgarno sequence, a start codon, and a synthetic structural gene. The preparation of these plasmids allows for high yields of the intermediate protein, which can be refolded to produce the therapeutically useful plasminogen activator recombinant scu-PA.

Career Highlights

Leopold Flohe' is associated with Gruenenthal GmbH, where he has contributed to advancements in biotechnology. His work has been pivotal in enhancing the efficiency of protein expression systems, which are crucial for the production of therapeutic proteins.

Collaborations

Leopold Flohe' has collaborated with notable colleagues such as Regina E Brigelius-Flohe' and Wolfgang Hillen. These collaborations have fostered a productive environment for innovation and research in the field of biotechnology.

Conclusion

Leopold Flohe' exemplifies the spirit of innovation in biotechnology through his patent and contributions to protein expression technology. His work continues to influence the development of therapeutic proteins, showcasing the importance of scientific research in improving healthcare solutions.