Leon R Lyle

Title: The Innovations of Leon R. Lyle

Introduction

Leon R. Lyle is a notable inventor based in Webster Groves, MO (US). He has made significant contributions to the field of bioactive peptides, holding a total of 11 patents. His work focuses on the development of stable analogs of peptides, which have important applications in medicine and biotechnology.

Latest Patents

One of his latest patents involves stable analogs of bioactive peptides containing disulfide linkages. This patent discloses methods for modifying disulfide linkages through four distinct approaches: sulfide contraction, isosteric substitution, thioketal expansion, and alkylation expansion. In sulfide contraction, the disulfide bond is replaced with a monosulfide bond, allowing for the binding of bifunctional effector molecules. Isosteric substitution replaces one sulfur atom with a carbon atom, while thioketal expansion inserts an alkylidene unit between the sulfur atoms. Lastly, alkylation expansion involves inserting an alkyl moiety between the two sulfur atoms.

Career Highlights

Throughout his career, Leon R. Lyle has worked with prominent organizations, including Mallinckrodt Medical, Inc. and the University of Michigan. His expertise in peptide chemistry has led to advancements in the field, particularly in the development of ultrasound contrast agents.

Collaborations

Leon has collaborated with esteemed colleagues such as Raghavan Rajagopalan and Steven L. Kunkel. These partnerships have further enhanced his research and innovation in the field of bioactive peptides.

Conclusion

Leon R. Lyle's contributions to the field of bioactive peptides and his innovative patents demonstrate his significant impact on medical and biotechnological advancements. His work continues to influence the development of new therapeutic agents and diagnostic tools.