Leon Golstein

Title: Leon Golstein: Innovator in Biologically Active Compounds

Introduction

Leon Golstein is a notable inventor based in Rehovot, Israel. He has made significant contributions to the field of polymer chemistry, particularly in the development of novel compounds that have applications in biologically active materials. His work has implications for various industries, including pharmaceuticals and biotechnology.

Latest Patents

Golstein holds a patent for "Dihaloisocyanide derivatives of polymers for coupling nucleophiles." This invention relates to key intermediates for producing biologically active compounds that are coupled to polymers. The general formula for these compounds is P--NCX₂, where X represents halogen atoms such as chlorine and bromine. The polymer backbone, designated as P, can be of the polyamide, polyester, or ureaformaldehyde type. The invention also covers compounds obtained by reacting P--NCX₂ with bifunctional or polyfunctional nucleophiles, which include hydrazides of dicarboxylic acids and various polyfunctional amines. These key intermediates can be directly coupled to biologically active macromolecules, including proteins and enzymes.

Career Highlights

Golstein is associated with Ramot University Authority for Applied Research and Industrial. His work at this institution has allowed him to explore innovative solutions in the field of polymer chemistry. His research has led to advancements that bridge the gap between basic science and practical applications in industry.

Collaborations

Some of his notable coworkers include Mordechai Sokolovsky and Amihay Freeman. Their collaborative efforts have contributed to the success of various research projects and innovations in the field.

Conclusion

Leon Golstein's contributions to the field of polymer chemistry and biologically active compounds highlight his role as an influential inventor. His patent on dihaloic compounds showcases the potential for innovative applications in biotechnology and pharmaceuticals.