Leon G J Frenken

Title: Leon G J Frenken: Innovator in Antibody Production

Introduction

Leon G J Frenken is a notable inventor based in Rotterdam, Netherlands. He has made significant contributions to the field of biotechnology, particularly in the production of antibodies derived from heavy chain immunoglobulins of camelidae. With a total of two patents to his name, his work has implications for various applications in medicine and research.

Latest Patents

Frenken's latest patents focus on innovative processes for producing antibodies or functionalized fragments derived from heavy chain immunoglobulins of camelidae. One of the key processes involves using a transformed lower eukaryotic host that contains an expressible DNA sequence encoding the antibody or its fragments. The antibodies produced are devoid of light chains and can be generated in molds or yeasts. His patents also describe the potential for grafting complementary determining regions (CDRs) onto the variable domain of the heavy chain immunoglobulin, enhancing the functionality of the antibodies. Additionally, the functionalized antibodies can be designed as fusion proteins, combining heavy chain immunoglobulins with other polypeptides, such as enzymes.

Career Highlights

Throughout his career, Leon G J Frenken has worked with several prominent companies, including Conopco, Inc. and Bac IP B.V. His experience in these organizations has contributed to his expertise in antibody production and biotechnology.

Collaborations

Frenken has collaborated with notable individuals in his field, including Raymond Hamers and Cecile Hamers-Casterman. These collaborations have likely enriched his research and development efforts.

Conclusion

Leon G J Frenken is a distinguished inventor whose work in antibody production has the potential to advance medical and biotechnological applications. His innovative processes and collaborations highlight his significant contributions to the field.