Location History:
- Sharnbrook, GB (2002)
- Bedford, GB (2007)
Company Filing History:
Years Active: 2002-2007
Title: Leon Frenken: Innovator in Antibody Fragment Production
Introduction
Leon Frenken is a notable inventor based in Bedford, GB. He has made significant contributions to the field of biotechnology, particularly in the production of antibody fragments. With a total of 2 patents to his name, Frenken's work has the potential to impact various applications in medicine and research.
Latest Patents
Frenken's latest patents focus on methods for producing antibody fragments. One of his patents describes an expression library comprising a repertoire of nucleic acid sequences cloned from a non-immunized source. Each nucleic acid sequence encodes at least part of a variable domain of a heavy chain derived from an immunoglobulin that is naturally devoid of light chains (VHH). The extent of sequence variability in the library is enhanced compared to the corresponding naive expression library by introducing mutations in one or more of the complementarity determining regions (CDRs) of the nucleic acid sequences. Additionally, alternative combinations of CDR and framework sequences not naturally present in the naive library repertoire are generated. This library can be utilized in preparing antibodies, particularly antibody fragments.
Career Highlights
Leon Frenken is associated with Unilever Patent Holdings B.V., where he continues to innovate in the field of biotechnology. His work has garnered attention for its potential applications in therapeutic development and research.
Collaborations
Frenken collaborates with Cornelis P Van Der Logt, contributing to advancements in their shared field of expertise.
Conclusion
Leon Frenken's innovative work in antibody fragment production showcases his commitment to advancing biotechnology. His patents reflect a deep understanding of molecular biology and its applications in medicine.