Lendell L Cummins

Title: Lendell L Cummins: Innovator in Nuclease Assays and Capillary Electrophoresis

Introduction

Lendell L Cummins is a notable inventor based in San Diego, California. He has made significant contributions to the field of biochemistry, particularly in the development of methods for analyzing nucleic acids. With a total of three patents to his name, Cummins has established himself as a key figure in innovative assay techniques.

Latest Patents

Cummins' latest patents include a fluorescence-based nuclease assay that provides methods for determining the stability of oligomeric compounds and their deletion sequences. This method utilizes capillary gel electrophoresis with laser-induced fluorescence detection. The assay involves treating fluorescently labeled oligomeric compounds with agents that have nuclease activity, resulting in a mixture that can be analyzed to yield quantitative concentrations of the original compound and its deletion sequences. Additionally, he has developed methods for detecting and quantifying target nucleobase sequences using capillary electrophoresis, which involves hybridizing peptide nucleic acid oligomers to the targets and performing electrophoresis to detect the labels.

Career Highlights

Throughout his career, Lendell L Cummins has worked with prominent companies such as Isis Pharmaceuticals, Inc. His work has focused on advancing the methodologies used in nucleic acid analysis, contributing to the broader field of molecular biology.

Collaborations

Cummins has collaborated with notable colleagues, including Susan M Freier and Richard Holmes Griffey. These partnerships have likely enhanced the development and application of his innovative techniques.

Conclusion

Lendell L Cummins is a distinguished inventor whose work in nucleic acid assays and capillary electrophoresis has made a significant impact in the field of biochemistry. His patents reflect a commitment to advancing scientific understanding and methodologies.