Company Filing History:
Years Active: 1992-2000
Title: Leland F. Velicer: Innovator in Avian Herpesvirus Research
Introduction
Leland F. Velicer is a prominent inventor based in East Lansing, Michigan. He has made significant contributions to the field of virology, particularly in the study of avian herpesviruses. With a total of seven patents to his name, Velicer's work has implications for vaccine development and diagnostic testing.
Latest Patents
Among his latest patents is the invention related to the Avian herpesvirus-A antigen precursor gene. This gene encodes for an A antigen precursor derived from an avian herpesvirus, specifically isolated from Marek's disease herpesvirus (MDHV). The gene is approximately 1.8-1.9 kbp and is found on a DNA fragment of about 2.35 kbp in size. It serves as a building block for vaccines and can be utilized as a diagnostic hybridization probe. This innovation facilitates the preparation of diagnostic test kits for MDHV through antigen production and subsequent antibody production. Additionally, it may provide regulatory elements such as signal peptides or promoters for use with other proteins.
Another significant patent involves the DNA segment encoding glycoproteins gD, gI, and gE from Marek's disease herpesvirus. This DNA is useful for probes to detect the herpesvirus DNA and for the expression of glycoproteins that can be used to produce antibodies specifically recognizing these glycoprotein antigens. Furthermore, the latter two genes may serve as potential insertion sites for foreign genes and as possible sites for gene inactivation to attenuate MDV field isolates for vaccine purposes.
Career Highlights
Leland F. Velicer is affiliated with Michigan State University, where he conducts his research and development work. His academic and professional journey has been marked by a commitment to advancing the understanding of avian herpesviruses and their implications for animal health.
Collaborations
Velicer has collaborated with notable colleagues such as Paul M. Coussens and Peter Brunovskis. These partnerships have contributed to the depth and breadth of his research endeavors.
Conclusion
Leland F. Velicer's innovative work in the field of avian herpesvirus research has led to significant advancements in vaccine development and diagnostic testing. His contributions continue to impact the scientific community and enhance our understanding of viral diseases.