Company Filing History:
Years Active: 1995-1997
Title: Lee J Silverberg: Innovator in Pharmaceutical Chemistry
Introduction
Lee J Silverberg is a notable inventor based in Fayetteville, NY (US). He has made significant contributions to the field of pharmaceutical chemistry, particularly in the development of etoposide phosphate and its applications.
Latest Patents
Silverberg holds 2 patents related to the process of preparing etoposide phosphate and etoposide. His innovative method involves coupling dibenzyl 4'-demethyl-4-epipodophyllotoxin-4'-phosphate with 2,3-di-O-benzyl-4,6-O-ethylidene-.alpha.,.beta.-D-glucopyranose in a solvent. The process includes the removal of protecting groups, recrystallization from methanol, and hydrogenation to produce etoposide phosphate in high yields. Additionally, he has developed a method where etoposide phosphate is treated with a phosphatase enzyme to yield etoposide.
Career Highlights
Silverberg is associated with Bristol-Myers Squibb Company, where he has been instrumental in advancing pharmaceutical research and development. His work has contributed to the understanding and production of vital cancer treatment compounds.
Collaborations
He has collaborated with notable coworkers such as Purushotham Vemishetti and John L Dillon, Jr., enhancing the innovative efforts within his team.
Conclusion
Lee J Silverberg's contributions to pharmaceutical chemistry, particularly through his patents and work at Bristol-Myers Squibb, highlight his role as a key innovator in the field. His research continues to impact the development of important therapeutic agents.
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