Laxmi Manral

Title: Laxmi Manral: Innovator in Pharmaceutical Chemistry

Introduction

Laxmi Manral is a distinguished inventor based in New Delhi, India. She has made significant contributions to the field of pharmaceutical chemistry, particularly in the synthesis of important compounds. Her innovative work has led to the development of a method for the preparation of fentanyl, a potent synthetic opioid.

Latest Patents

Laxmi Manral holds 1 patent for her invention titled "Method for the preparation of fentanyl." This method involves a series of chemical reactions, starting with the reaction of 4-piperidone hydrochloride monohydrate with aniline in a reducing environment to produce 4-anilinopiperidine (4-AP). The 4-AP is then reacted with phenethyl halide under reflux conditions in a highly alkaline medium to yield 4-anilino-N-phenethylpiperidine. Finally, this compound is converted to fentanyl by reacting it with propionyl chloride in the presence of halogenated hydrocarbons, followed by isolation and purification through solvent extraction and crystallization from petroleum ether at a temperature ranging from 60-80°C.

Career Highlights

Throughout her career, Laxmi has worked with notable organizations, including the Defence Research Development Organisation and the Director General of Defence Research and Development Organisation. Her work in these institutions has allowed her to contribute to significant advancements in research and development.

Collaborations

Laxmi has collaborated with esteemed colleagues such as Pradeep Kumar Gupta and Kumaran Ganesan. These collaborations have further enriched her research and innovation efforts.

Conclusion

Laxmi Manral is a remarkable inventor whose contributions to pharmaceutical chemistry have made a lasting impact. Her innovative methods and collaborations highlight her dedication to advancing the field.