Lawrence M Ryan

Title: Innovations of Lawrence M Ryan

Introduction

Lawrence M Ryan is a notable inventor based in Wauwatosa, WI (US). He has made significant contributions to the field of biotechnology, particularly in the area of nucleotide pyrophosphohydrolases. His work has implications for understanding cellular processes and potential therapeutic applications.

Latest Patents

Lawrence M Ryan holds a patent for a "Cloned nucleotide pyrophosphohydrolase and uses thereof." This patent describes the cloning and sequencing of the cDNA encoding the 61 kD active fragment of a unique porcine chondrocyte nucleotide pyrophosphohydrolase (NTPPHase). The research involved hybridizing degenerate oligonucleotides to porcine chondrocyte cDNA and amplifying DNA using polymerase chain reaction (PCR). The resulting cloned cDNA was 2509 bp in length, predicting a 459 amino acid protein. Analysis confirmed the uniqueness of this amino acid sequence, with limited homology detected to known proteins.

Career Highlights

Lawrence M Ryan is associated with the MCW Research Foundation, Inc., where he has contributed to groundbreaking research in his field. His work has advanced the understanding of nucleotide pyrophosphohydrolases and their potential applications in medicine.

Collaborations

He has collaborated with notable coworkers, including Ikuko Masuda and Joseph T Barbieri, contributing to the advancement of research in biotechnology.

Conclusion

Lawrence M Ryan's innovative work in cloning nucleotide pyrophosphohydrolases showcases his significant contributions to biotechnology. His research continues to influence the field and holds promise for future applications.