Lawrence C Mahan

Title: Innovations and Contributions of Lawrence C Mahan

Introduction

Lawrence C Mahan is a notable inventor based in Bethesda, MD (US). He has made significant contributions to the field of biochemistry and pharmacology, holding a total of 4 patents. His work primarily focuses on methods related to G-protein coupled receptors, which are crucial in various biological processes.

Latest Patents

Mahan's latest patents include a method of identifying ligands and antagonists of G-protein coupled receptors. This invention relates to a method that identifies ligands and antagonists that bind to cloned G.sub.8 or G.sub.1-coupled receptors. Additionally, he has developed a patent concerning the cDNA encoding a rat D.sub.1 dopamine receptor linked to adenylyl cyclase. This invention allows for the assessment of agonist and antagonist drugs' affinities and efficacies with the D.sub.1 receptor. Furthermore, it includes a recombinant DNA construct that can be expressed in various host cells, including mammalian cells.

Career Highlights

Throughout his career, Mahan has worked with esteemed organizations, including the United States of America as represented by the Secretary of Health and the Department of Health. His innovative work has contributed to advancements in understanding receptor functions and drug interactions.

Collaborations

Mahan has collaborated with notable colleagues such as David Robert Sibley and Frederick J Monsma, Jr. These collaborations have further enhanced the impact of his research and inventions in the scientific community.

Conclusion

Lawrence C Mahan's contributions to the field of biochemistry through his patents and collaborations have significantly advanced our understanding of G-protein coupled receptors. His work continues to influence research and development in pharmacology and related fields.