Location History:
- Boston, MA (US) (1997 - 2002)
- Brookline, MA (US) (1999 - 2004)
Company Filing History:
11 out of 1,386 
7 out of 2,896 
Years Active: 1997-2004
Title: Lawrence C. Madoff: Pioneer in Vaccine Development
Introduction
Lawrence C. Madoff is a prominent inventor based in Boston, MA, known for his substantial contributions to the field of vaccine research. With an impressive portfolio comprising 11 patents, Madoff has made significant strides in the understanding and development of vaccines, particularly against bacterial infections.
Latest Patents
Madoff's most recent innovations include two notable patents. The first patent, titled "Capsular Polysaccharides from Enterococci," focuses on a method of purifying polysaccharides that can induce high titers of opsonic antibodies effective against enterococcal bacteria. Furthermore, this invention encompasses the antigens produced through the purification process and the associated vaccines.
The second patent is centered around a "Group B Streptococcus Vaccine." This vaccine is designed to protect recipients from infections caused by group B Streptococcus. It incorporates polysaccharide-protein moieties or protein moieties without polysaccharides. The innovative vaccine may comprise a group B Streptococcus polysaccharide conjugated with the N-terminal region of the epsilon antigen, alongside various configurations of polysaccharide-protein units to elicit protective antibody responses. Additionally, the invention discusses a passive vaccine derived from immunization with either the capsular polysaccharide-protein conjugate or non-conjugated proteins.
Career Highlights
Lawrence C. Madoff has had a distinguished career, contributing to prestigious organizations such as Brigham and Women's Hospital and The General Hospital Corporation. His work in these institutions has facilitated innovative research and development, particularly in the realm of infectious diseases and vaccines.
Collaborations
Throughout his career, Madoff has collaborated with notable figures such as James L. Michel and Dennis L. Kasper. These partnerships have fostered an environment of innovation, enabling the development of groundbreaking treatments and vaccines that address critical health challenges.
Conclusion
Lawrence C. Madoff’s commitment to vaccine research and his impressive patent portfolio underscore his role as a leading inventor in the field. His contributions not only advance scientific understanding but also pave the way for effective vaccinations that protect public health. As he continues his work, Madoff's innovations are expected to further impact the field of medicine positively.