Lawrence A Quilliam

Title: Innovations of Lawrence A Quilliam

Introduction

Lawrence A Quilliam is a notable inventor based in Chapel Hill, NC (US). He has made significant contributions to the field of biochemistry, particularly through his innovative work on peptides that bind to Src homology region (SH3) domains of proteins. With a total of four patents to his name, Quilliam's research has implications for understanding protein interactions and developing new therapeutic strategies.

Latest Patents

Quilliam's latest patents include "Src SH3 binding peptides and methods of isolating and using same." This invention discloses peptides that exhibit both general and specific binding affinities for SH3 domains of proteins. The peptides have been isolated from phage-displayed random peptide libraries, which were screened for isolates that bind to bacterial fusion proteins of SH3 domains and glutathione S-transferase (GST). The preferred peptides feature a core 7-mer sequence, along with additional amino acid residues, resulting in a total length of 9 to 45 amino acids. These peptides demonstrate preferential binding affinities for certain SH3 domains, particularly those associated with the Src-family of proteins. In vitro and in vivo results validate the biochemical activity of these peptides.

Another significant patent is focused on "Nck SH3 binding peptides," which also involves peptides with binding affinities for SH3 domains. Similar to his previous work, these peptides have been isolated from phage-displayed libraries and exhibit specific binding affinities for the Src-family of proteins. The detailed characterization of these peptides further enhances the understanding of protein interactions.

Career Highlights

Quilliam has had a distinguished career, contributing to both academic and research institutions. He has worked at the University of North Carolina at Chapel Hill, where he has been involved in various research projects that explore the biochemical properties of peptides and their applications in medicine.

Collaborations

Throughout his career, Quilliam has collaborated with notable colleagues, including Andrew B Sparks and Brian K Kay. These collaborations have enriched his research and expanded the impact of his inventions in the scientific community.

Conclusion

Lawrence A Quilliam's innovative work in the field of peptide research has led to significant advancements in understanding protein interactions. His contributions through multiple patents highlight the importance of his research in biochemistry and its potential applications in therapeutic development.