Company Filing History:
Years Active: 1997
Title: Laurie J Jones: Innovator in Fluorescent Dyes
Introduction
Laurie J Jones is a notable inventor based in Monroe, OR (US). He has made significant contributions to the field of fluorescent dyes, particularly in the preparation and use of dyes for nucleic acid analysis. With a total of 2 patents, his work has advanced the sensitivity and effectiveness of various staining techniques.
Latest Patents
One of his latest patents is titled "Substituted unsymmetrical cyanine dyes with selected permeability." This invention describes the preparation and use of fluorescent stains for nucleic acids derived from unsymmetrical cyanine dyes. The dyes comprise a substituted benzazolium ring system linked by a methine bridge to a pyridinium or quinolinium ring system. The presence of a heteroatom-containing substituent enhances sensitivity to oligonucleotides and larger nucleic acid polymers across a wide range of cells and gels. This innovation is particularly useful for analyzing cell structure, membrane integrity, or function.
Another significant patent is "Non-specific protein staining using merocyanine dyes." This invention outlines the use of various merocyanine dyes and substituted merocyanine dyes for detecting and quantifying poly(amino acids), including peptides, polypeptides, and proteins. The labeled proteins or peptides exhibit strong fluorescence enhancement, making them easily detectable. This method of staining is highly sensitive, facile, and relatively non-selective, allowing for detection in solution, electrophoretic gels, and on solid supports.
Career Highlights
Laurie J Jones is associated with Molecular Probes, Inc., where he continues to innovate in the field of fluorescent dyes. His work has had a profound impact on the scientific community, particularly in the areas of molecular biology and biochemistry.
Collaborations
He has collaborated with notable coworkers, including Victoria L Singer and Richard P Haugland, contributing to advancements in the field through teamwork and shared expertise.
Conclusion
Laurie J Jones is a distinguished inventor whose work in fluorescent dyes has significantly enhanced the sensitivity and effectiveness of nucleic acid and protein analysis. His contributions continue to influence research and applications in molecular biology.