Company Filing History:
Years Active: 2008
Title: Innovative Contributions of Laurent Coen in Neuroscience
Introduction
Laurent Coen is a notable inventor based in Montreuil, France, recognized for his significant contributions to neuroscience through innovative research. His work primarily focuses on the development of hybrid proteins that facilitate the transport of biological activities into the central nervous system (CNS).
Latest Patents
Laurent Coen holds a patent for his invention titled "Hybrid proteins that migrate retrogradely and transynaptically into the CNS." This patent outlines a remarkable application of the non-toxic proteolytic C fragment of tetanus toxin (TTC peptide), which possesses the unique ability to bind nerve cells and be retrogradely transported through synapses, akin to the native toxin. The invention describes a hybrid protein encoded by the IacZ-TTC gene fusion, which retains crucial biological functions in vivo, specifically the retrograde transynaptic transport of the TTC fragment alongside β-gal enzymatic activity. Following intramuscular injection, this enzymatic activity could be traced in motoneurons and associated neurons within the brainstem, suggesting a strategy for effective delivery of biological activity to neurons extending from the periphery to the CNS. Additionally, this hybrid protein presents potential for mapping the synaptic connections between neural cells, adding another layer of utility to its application.
Career Highlights
Laurent Coen is affiliated with the prestigious Institut Pasteur, an institution renowned for its pioneering research in microbiology and immunology. His work at the institute exemplifies his commitment to advancing scientific knowledge and innovation in the field of neuroscience.
Collaborations
Throughout his career, Laurent has collaborated with esteemed colleagues like Rosario Osta Pinzolas and Philippe Brulet. These collaborations not only reflect his ability to work within dynamic research teams but also enhance the impact of his innovations in the scientific community.
Conclusion
Laurent Coen's innovative approach to neuroscience through his patented hybrid proteins showcases the potential for groundbreaking advancements in understanding and treating neurological conditions. His contributions, backed by rigorous research and collaboration, position him as a key figure in the ongoing exploration of the complexities of the central nervous system.