Lauren Silverman

Title: The Innovative Contributions of Lauren Silverman

Introduction

Lauren Silverman is a notable inventor based in Ossining, NY, who has made significant contributions to the field of cellular biology. With a total of three patents to her name, Silverman has focused her research on the interaction of cellular proteins and their implications in drug screening and development.

Latest Patents

One of Silverman's latest patents is titled "Cell surface proteins and use thereof as indicators of activation of cellular signal transduction pathways." This invention provides a rapid, reproducible, and robust assay system for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of cellular proteins, such as receptors or ion channels. The assay enables the rapid screening of large numbers of compounds to identify those that act as agonists or antagonists to the bioactivity of the cellular protein. In this system, the cell is treated with a compound, and the functional interaction of this compound with a cellular receptor yields a detectable signal that can be specifically measured. The assays include methods for identifying compounds that specifically modulate heterologous receptors coupled to the pheromone response pathway in yeast, making them particularly useful for identifying specific agonists and antagonists of G protein-coupled receptors.

Another significant patent involves "Yeast cells having mutations in stp22 and uses therefor." This invention provides yeast cells that contain a mutation in the endogenous yeast stp22 gene and express a heterologous G protein-coupled receptor. These yeast cells display enhanced sensitivity to ligand-induced stimulation of heterologous G protein-coupled receptors, thereby improving their properties in drug screening assays.

Career Highlights

Throughout her career, Lauren Silverman has worked with various companies, including Cadus Pharmaceutical Corp. and Cadus Technologies, Inc. Her work in these organizations has contributed to advancements in pharmaceutical research and development.

Collaborations

Silverman has collaborated with notable colleagues, including Kirill Ostanin and Mary Cismowski, who have contributed to her research endeavors.

Conclusion

Lauren Silverman's innovative work in cellular biology and her patented inventions have made a significant impact on drug screening methodologies. Her contributions continue to influence the field and pave the way for future advancements in pharmaceutical research.