Company Filing History:
Years Active: 1989-1993
Title: Laura J Creemer: Innovator in Pharmaceutical Chemistry
Introduction
Laura J Creemer is a distinguished inventor based in Indianapolis, IN (US). She has made significant contributions to the field of pharmaceutical chemistry, holding a total of 4 patents. Her work focuses on innovative processes for the preparation of important compounds used in medicine.
Latest Patents
One of her latest patents is titled "Process for the preparation of nojirimycin and related compounds." This invention describes an efficient new route for the preparation of (+)-nojirimycin and (+)-1-deoxynojirimycin, involving the stereoselective reductive amination of 1,2-O-isopropylidene-5-oxo-.alpha.-D-glucuronolactone. The process utilizes specific oximes of the 5-oxo compound to achieve the desired results. Another notable patent is related to the "Intermediates in a process for the preparation of castanospermine." In this patent, castanospermine is synthesized starting from 5-(t-BOC)amino-5-deoxy-1,2-O-isopropylidene-.alpha.-D-glucuronolactone, where two additional carbons are added using ethyl acetate and a strong base. The resulting cyclic hemiketal undergoes a series of reductions, with the removal of protecting groups, to yield castanospermine.
Career Highlights
Laura J Creemer is currently employed at Merrell Dow Pharmaceuticals, where she continues to advance her research and development efforts. Her innovative approaches have positioned her as a key figure in her field, contributing to the development of new pharmaceutical compounds.
Collaborations
Throughout her career, Laura has collaborated with notable colleagues, including Peter Biagio Anzeveno and Paul T Angell. These partnerships have enhanced her research and expanded the impact of her inventions.
Conclusion
Laura J Creemer is a prominent inventor whose work in pharmaceutical chemistry has led to significant advancements in the preparation of important compounds. Her contributions continue to influence the field and demonstrate the importance of innovation in medicine.