Laura E Deforge

Title: Innovations of Laura E Deforge in Cholesterol Imaging

Introduction

Laura E Deforge is an accomplished inventor based in Ann Arbor, MI (US). She has made significant contributions to the field of medical imaging, particularly in the development of novel radioiodinated analogues of cholesterol esters. Her work has implications for enhancing imaging techniques for adrenal glands.

Latest Patents

Laura E Deforge holds a patent for "Radioiodinated arylaliphatic ether analogues of cholesterol." This patent describes innovative radioiodinated analogues of naturally-occurring cholesterol esters, which are selective for low-density lipoproteins. These compounds have been shown to be effective imaging agents for adrenal glands. The arylaliphatic cholesteryl ethers have a general formula where X is a radioactive isotope of iodine and n is an integer between 1 and 20. Two illustrative examples include m-iodobenzyl cholesteryl ether and 12-(m-iodophenyl) dodecyl cholesteryl ether, which were radiolabeled with ¹²⁵I through an isotope exchange reaction. Tissue distribution studies indicate significant accumulation of these cholesteryl ethers in the adrenal glands and, to a lesser extent, in the liver. The cholesteryl ethers selectively incorporate into plasma lipoproteins, as determined by polyacrylamide gel electrophoresis.

Career Highlights

Laura E Deforge is affiliated with the University of Michigan, where she continues her research and development in the field of medical imaging. Her innovative work has garnered attention and recognition within the scientific community.

Collaborations

Laura has collaborated with notable colleagues, including Raymond E Counsell and Mohamed K Ruyan, contributing to advancements in her field.

Conclusion

Laura E Deforge's contributions to the development of radioiodinated cholesteryl ethers represent a significant advancement in medical imaging technology. Her innovative work continues to impact the field positively.