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Title: Larry Witte: Innovator in Stem Cell Research
Introduction
Larry Witte is a notable inventor based in Stormville, NY, recognized for his significant contributions to the field of stem cell research. With two patents to his name, Larry has developed innovative methods that are influencing the landscape of medical therapies involving stem cells.
Latest Patents
One of Larry's latest inventions is directed towards a purified population of mammalian endothelial, muscle, or neural stem cells. This invention not only focuses on isolating such populations of cells but also provides methods for their application in treating mammals. Furthermore, it addresses the creation of vectors for gene therapy and methods for conducting gene therapy using these vectors.
Larry's second patent involves the use of delta-like protein to inhibit the differentiation of stem cells. His research indicates that primitive hematopoietic stem cells are closely tied to specific microenvironments known as "niches," which provide critical molecular signals regulating stem cell differentiation and self-renewal. Larry’s extensive investigations have revealed a cDNA that encodes a cell surface glycoprotein, dlk/Pref-1, which is instrumental in maintaining repopulating stem cells. This discovery underscores the potential of dlk protein in hematopoietic stem/progenitor cell regulation.
Career Highlights
Larry has made significant academic contributions during his career, working with esteemed institutions such as Cornell Research Foundation Inc. and the Sloan-Kettering Institute for Cancer Research. His work in these organizations has contributed to advancements in the understanding and manipulation of stem cells for therapeutic purposes.
Collaborations
Throughout his career, Larry has collaborated with distinguished colleagues, including Shahin Rafii and Malcolm A.S. Moore. These collaborations have further enriched his research pursuits and have played a vital role in the progression of his innovative projects.
Conclusion
Larry Witte's contributions to stem cell research exemplify the impact that innovative thinking can have on medicine. His patents are paving the way for new treatments and therapies that may one day enhance the quality of life for countless individuals. His ongoing work and collaborations continue to inspire advancements in the field of regenerative medicine.