Larry J Fretto

Title: Larry J Fretto - An Innovator in Immunoglobulin Polypeptides

Introduction

Larry J Fretto, an accomplished inventor based in Belmont, California, has made significant contributions to the field of immunology through his innovative ideas and inventions. With a remarkable portfolio of seven patents, Fretto's research has focused on creating therapeutic advancements in receptor inhibition.

Latest Patents

Among his latest inventions, one noteworthy patent includes the development of inhibitory immunoglobulin polypeptides that specifically target the human PDGF beta receptor. This invention is directed toward the creation of immunoglobulin polypeptides that bind to the extracellular domain of this receptor. The binding action has proven to inhibit PDGF-induced receptor activation, which is evidenced by decreased receptor phosphorylation, inhibited dimerization, and reduced PDGF-mediated processes such as mitogenesis, chemotaxis, and cell migration. Additionally, the patent encompasses nucleic acids that encode these immunoglobulin polypeptides, emphasizing their potential diagnostic and therapeutic applications. Another significant patent in his portfolio involves platelet ADP receptor inhibitors, showcasing his diverse impact on health-related inventions.

Career Highlights

Larry has made substantial contributions while working at notable organizations such as Cor Therapeutics, Inc. and the University of California. His tenure at these institutions has provided him with opportunities to engage in groundbreaking research and development projects that further push the boundaries of medical science.

Collaborations

Over his career, Larry J Fretto has collaborated with esteemed colleagues, including David Lawrence Wolf and James E Tomlinson. Their teamwork and shared vision have played a crucial role in the advancement of innovative therapies and have contributed to the successful attainment of multiple patents.

Conclusion

Larry J Fretto stands as a testament to the significant impact that inventive minds can have on science and healthcare. His development of immunoglobulin polypeptides and other therapeutic inventions highlights not only his dedication to research but also the potential for future advancements in medicine. As his work continues, the medical community eagerly anticipates the beneficial applications of his patented innovations.