Company Filing History:
Years Active: 1998
Title: The Innovations of Larry Gentry: Cloning and Expression of TGF-β1
Introduction: Larry Gentry, a notable inventor based in Maumee, Ohio, has made significant contributions to the field of biotechnology. His work primarily focuses on the cloning and expression of simian transforming growth factor beta 1 (TGF-β1), which holds critical implications for medical research and therapeutic applications. With one important patent to his name, Gentry's innovations continue to influence the pharmaceutical industry.
Latest Patents: Larry Gentry holds a patent for the "Cloning and expression of simian transforming growth factor beta 1." This invention describes a novel method to express recombinant TGF-β1 at high levels in Chinese hamster ovary (CHO) cells through the amplification of the dihydrofolate reductase (dhfr) gene. The methodology involves utilizing transcription control by the SV40 early promoter and stepwise selection of transfected cells under increasing concentrations of methotrexate. His groundbreaking work has yielded cell lines that secrete substantial amounts of TGF-β1 protein, vital for advancing research in therapeutic treatments.
Career Highlights: Larry Gentry is associated with the Bristol-Myers Squibb Pharmaceutical Research Institute in Seattle, where he has dedicated his expertise to biopharmaceutical development. His role involves innovating processes that can significantly enhance protein expression systems, contributing to advancements in drug formulation and delivery.
Collaborations: Throughout his career, Gentry has collaborated with esteemed colleagues such as Anthony F. Purchio and Daniel Twardzik. These partnerships have enabled him to leverage collective expertise in the field, further advancing the understanding and application of recombinant proteins in the biotechnology sector.
Conclusion: Larry Gentry's contributions to the cloning and expression of TGF-β1 highlight his innovative spirit and dedication to advancing medical research. With his patent and impactful collaborations, Gentry exemplifies the role of inventors in transforming scientific discoveries into practical applications, paving the way for future breakthroughs in biopharmaceuticals.