This inventor holds 1 USPTO granted patent. Top assignee: Other. Active years: 2003.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile
Company Filing History:
1 out of 834,708 Years Active: 2003
Title: Innovations in Malaria Vaccine Development by Lap-Yin Pang
Introduction
Lap-Yin Pang is a notable inventor based in Hong Kong, CN. He has made significant contributions to the field of immunology, particularly in the development of malaria vaccines. His innovative approach utilizes the silkworm/baculovirus system to produce recombinant proteins that can aid in malaria immunization.
Latest Patents
Lap-Yin Pang holds a patent for a malaria immunogenic composition. The patent details the use of the silkworm/baculovirus system to produce recombinant Major Merozoite Surface Protein 1 (MSP1). This method is advantageous due to its low cost and potential for high yield. The MSP1 (3D7 sequence) was cloned into the baculovirus, BmNPV, with the melittin signal sequence. The recombinant virus, BmNPV-Sp42, was used to infect silkworms for the expression of MSP1 (Sp42). One recombinant clone expressed a high level of Sp42, producing an estimated 0.5 mg of antigen within a single worm. The Sp42 was recognized by monoclonal and polyclonal antibodies specific for parasite MSP1 in direct binding and competitive binding ELISAs. This suggests that Sp42 possesses antigenic determinants similar to parasite MSP1. Immunogenicity studies performed in rabbits showed that Sp42 induced high titers of antibodies crossreactive with MSP1. Specificity analyses indicated that anti-Sp42 antibodies reacted primarily against conserved determinants on MSP1-19. The results demonstrated that the silkworm expression system can produce recombinant MSP1 that are antigenically and immunogenically comparable to other recombinant MSP1 antigens expressed in different eukaryotic systems. The low cost and high level of protein expression make it an attractive alternative for the development of a human malaria vaccine.
Career Highlights
Lap-Yin Pang's career is marked by his dedication to advancing vaccine technology. His innovative research has the potential to significantly impact public health by providing a more effective means of combating malaria.
Collaborations
Lap-Yin Pang has collaborated with notable colleagues, including George S N Hui and Walter K K Ho. Their combined expertise has contributed to the success of his research endeavors.
Conclusion
Lap-Yin Pang's work in the field of malaria vaccine development showcases the importance of innovative approaches in addressing
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile