Company Filing History:
Years Active: 2003-2006
Title: Innovations of Lambertus J Oehlen
Introduction
Lambertus J Oehlen is a notable inventor based in Tarrytown, NY (US). He has made significant contributions to the field of cellular signal transduction through his innovative patents. With a total of 2 patents to his name, Oehlen's work focuses on the detection of functional interactions between compounds and cellular components.
Latest Patents
Oehlen's latest patents include a system for detecting functional interactions between a compound and a cellular signal transduction component. This invention provides a rapid, reproducible, and robust assay system for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of cellular proteins, such as receptors or ion channels. The assay enables the rapid screening of large numbers of compounds to identify those that act as agonists or antagonists to the bioactivity of the cellular protein. In this system, the first cell is treated with a compound, and the functional interaction of this compound with a cellular receptor yields a secreted signal. A second cell, which bears a receptor for this secreted signal, utilizes an indicator gene in a signaling pathway coupled to this second receptor. The assays include methods for identifying compounds that specifically modulate heterologous receptors coupled to the pheromone response pathway in yeast. These assays are particularly useful for identifying specific agonists and antagonists of G protein-coupled receptors.
Career Highlights
Oehlen is associated with Cadus Technologies, Inc., where he continues to contribute to advancements in pharmaceutical research and development. His work has been instrumental in enhancing the understanding of cellular interactions and the development of new therapeutic compounds.
Conclusion
Lambertus J Oehlen's innovative contributions to the field of cellular signal transduction exemplify the impact of dedicated inventors in advancing pharmaceutical science. His patents reflect a commitment to improving the methods of drug discovery and development.
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