Location History:
- Ottawa, CA (2015 - 2020)
- Gloucester, CA (2022)
Company Filing History:
4 out of 1,012 
1 out of 832,718 Years Active: 2015-2022
Title: Lakshmi Krishnan: Innovator in Cancer Treatment and Vaccine Development
Introduction
Lakshmi Krishnan is a prominent inventor based in Ottawa, Canada. She has made significant contributions to the fields of cancer treatment and vaccine development. With a total of 5 patents to her name, her work is recognized for its innovative approaches to medical challenges.
Latest Patents
Among her latest patents is the development of CEACAM6 CAR immune cells to treat cancers. This chimeric antigen receptor (CAR) binds to CEACAM6, an epitope or fragment thereof, or a variant thereof. Another notable patent involves sulfated-glycolipids as adjuvants for vaccines. This synthetic charged glycolipid comprises a sulfated saccharide group covalently linked to the tree sn-1 hydroxyl group of the glycerol backbone of an archaeal core lipid via a beta linkage. The synthetic charged glycolipids include compounds of formula I wherein n is 0 or 1; R is hydrogen or hydroxyl; and Y is hydrogen or a sulfate group, with at least one Y being a sulfate group. These sulfated glycolipids produce stable archaeosomes at a mol % ratio of from 100:0 to 30:70 (sulfated glycolipid:uncharged glycolipid) and induce a protective immune response, including CD8 and CD4 T cell responses. Archaeosomes comprising the sulfated glycolipids described have desirable adjuvant properties, particularly when mixed with uncharged glycolipid at a mol % ratio of about 50:50.
Career Highlights
Lakshmi has worked with the National Research Council of Canada, where she has contributed to various research initiatives. Her innovative work has positioned her as a leader in her field, particularly in the development of novel therapeutic strategies.
Collaborations
Throughout her career, Lakshmi has collaborated with notable colleagues, including Kevin Young and Dennis M. Whitfield. These collaborations have further enhanced her research and development efforts.
Conclusion
Lakshmi Krishnan's contributions to cancer treatment and vaccine development highlight her role as a leading inventor in the medical field. Her innovative patents and collaborations reflect her commitment to advancing healthcare solutions.