Company Filing History:
Years Active: 2001-2008
Title: Kyoung Ae Kang: Innovator in Gene Therapy for Orthopedic Diseases
Introduction
Kyoung Ae Kang is a notable inventor based in Kyunggi-do, South Korea. He has made significant contributions to the field of gene therapy, particularly in the treatment of orthopedic diseases. With a total of 3 patents to his name, Kang's work is paving the way for innovative medical treatments.
Latest Patents
One of Kang's latest patents focuses on gene therapy using TGF-β. This invention is related to a cell-mediated gene therapy treatment for orthopedic diseases, utilizing a member of the transforming growth factor-β (TGF-β) superfamily. The patent demonstrates TGF-β gene therapy as a new treatment method for degenerative arthritis. In his research, TGF-β cDNA expression vectors were transfected into fibroblasts (NIH 3T3-TGF-β1), which were then injected into rabbit Achilles tendons and knee joints with artificially created cartilage defects. Intratendinous injections were performed to determine the optimal concentration for in vivo expression. A partially defected cartilage model was created to simulate degenerative arthritis of the knee joint. The results showed that the partial cartilage defect treated with the cell-mediated gene therapy procedure was covered by newly formed hyaline cartilage, indicating that the cells survived and stimulated matrix formation in this area. Conversely, completely denuded cartilage areas were covered by fibrous collagen.
Career Highlights
Kyoung Ae Kang has worked with several companies, including Tissuegene, Inc. and Tissuegene Co. His innovative research and development efforts have contributed to advancements in gene therapy and orthopedic treatments.
Collaborations
Kang has collaborated with notable colleagues such as Moon Jong Noh and Kwan Hee Lee, further enhancing the impact of his work in the field.
Conclusion
Kyoung Ae Kang's contributions to gene therapy represent a significant advancement in the treatment of orthopedic diseases. His innovative approach and dedication to research continue to inspire progress in medical science.