Company Filing History:
Years Active: 1998
Title: Innovations in Gene Therapy: The Contributions of Kyonggeun Yoon
Introduction
Kyonggeun Yoon, based in Berwyn, Pennsylvania, is an accomplished inventor known for his significant contributions to gene therapy. His pioneering work focuses on developing methods and compounds designed to address diseases caused by genetic mutations, emphasizing innovative approaches to therapeutic interventions.
Latest Patents
Yoon holds a patent for "Methods and compounds for curing diseases caused by mutations." This groundbreaking invention concerns the application of duplex oligonucleotides that combine both 2'-deoxyribonucleotides and ribonucleotides, enabling base pairing between these nucleotides. The oligonucleotide sequences are crafted to match the 3' and 5' ends of a preselected target gene within a cell, allowing for targeted modifications. The introduction of these oligonucleotides into a cell's nucleus leads to alterations in the target gene, effectively creating what Yoon terms Chimeric Repair Vectors (CRV). This methodology shows promise in addressing conditions such as Sickle Cell Disease and β-thalassemia, providing high correction rates without the necessity of selecting treated hematopoietic stem cells for impactful therapeutic results. An interesting aspect of the invention includes the use of ribose moieties in the nucleotides, which contain methylated 2'-oxygens.
Career Highlights
Kyonggeun Yoon is associated with Thomas Jefferson University, where he engages in cutting-edge research and innovation. His focus on genetic therapies has positioned him at the forefront of the fight against hemoglobinopathies. His work has substantial implications for patient treatment protocols and advancements in genetic medicine.
Collaborations
Throughout his career, Yoon has collaborated with esteemed colleagues, including Eric B. Kmiec and Allyson D. Cole-Strauss. These collaborations foster a synergistic environment that enhances research output and drives forward the understanding and treatment of genetic disorders.
Conclusion
Kyonggeun Yoon's contributions to the field of gene therapy exemplify the power of innovative thinking in addressing complex medical challenges. His patent on Chimeric Repair Vectors serves as a testament to his role as a leading inventor in genetic research, with the potential to significantly improve the quality of life for patients suffering from genetic diseases. As the field of biotechnology continues to evolve, Yoon's work remains a critical part of advancing therapeutic strategies and enhancing patient outcomes.