Kyle Newton Plunkett

Title: Innovations of Kyle Newton Plunkett

Introduction

Kyle Newton Plunkett is an accomplished inventor based in Carbondale, IL (US). He has made significant contributions to the field of mass spectrometry through his innovative research and development. His work focuses on enhancing the efficiency of matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS).

Latest Patents

Kyle holds a patent for his invention titled "Alpha-cyano-4-hydroxy-3-iodocinnamic acid as a matrix in MALDI mass spectrometry." This patent describes a heavy-atom derivative of CHCA, a primary matrix molecule for MALDI-MS. The new matrix molecule, α-cyano-4-hydroxy-3-iodocinnamic acid (CHICA), has been synthesized and purified. It is characterized by H NMR and mass spectrometry. CHICA has been shown to increase MALDI-MS yield for test analytes such as human angiotensin II and sex pheromone inhibitor when compared to both CHCA and an alternative heavy-atom CHCA derivative matrix. The optimal CHICA matrix concentration is determined to be 4 mg/mL. For analyte concentrations below 0.001 mg/mL, the analyte ion yield is comparable for CHICA and CHCA. However, for concentrations above this threshold, CHICA results in higher analyte yield and significantly lower relative standard deviation.

Career Highlights

Kyle is affiliated with Southern Illinois University, where he conducts his research and development work. His contributions to the field of mass spectrometry have been recognized for their innovative approach and practical applications.

Collaborations

Kyle has collaborated with notable colleagues, including Kristopher M Kirmess and Gary R Kinsel. These collaborations have further enhanced the research and development efforts in the field of mass spectrometry.

Conclusion

Kyle Newton Plunkett's innovative work in mass spectrometry exemplifies the impact of research and development in scientific advancements. His contributions continue to influence the field and pave the way for future innovations.