Kyle Hoffman

Title: Innovations of Inventor Kyle Hoffman

Introduction

Kyle Hoffman is an accomplished inventor based in New Haven, CT (US). She has made significant contributions to the field of biotechnology, particularly in the area of polypeptide synthesis. Her innovative work has led to the development of methods that enhance the production of proteins containing selenocysteine residues.

Latest Patents

Hoffman holds a patent for "Compositions and methods for making selenocysteine containing polypeptides." This patent describes non-naturally occurring tRNA and methods for using them to achieve recombinant expression of proteins engineered to include one or more selenocysteine residues. The non-naturally occurring tRNA can be utilized for the recombinant manufacture of selenocysteine containing polypeptides encoded by mRNA without the need for an SECIS element. In various embodiments, these polypeptides are produced by co-expressing a non-naturally occurring tRNA in a recombinant expression system, such as with SerRS, EF-Tu, SelA, or PSTK and SepSecS, along with an mRNA that has at least one codon recognizing the anticodon of the non-naturally occurring tRNA. She has 1 patent to her name.

Career Highlights

Hoffman is affiliated with Yale University, where she continues her research and development in the field of biotechnology. Her work has garnered attention for its potential applications in various industries, including pharmaceuticals and agriculture.

Collaborations

Some of her notable coworkers include Dieter Soll and Takahito Mukai, who have collaborated with her on various projects related to her research.

Conclusion

Kyle Hoffman is a pioneering inventor whose work in the synthesis of selenocysteine containing polypeptides is paving the way for advancements in biotechnology. Her contributions are significant and continue to influence the field positively.