Company Filing History:
Years Active: 2023-2025
Title: Innovations of Inventor Kyle Brown
Introduction
Kyle Brown is an accomplished inventor based in Madison, WI (US). He has made significant contributions to the field of proteomics through his innovative inventions. With a total of 3 patents, Brown's work focuses on developing advanced surfactants that enhance protein analysis.
Latest Patents
One of his latest patents involves the creation of photo-cleavable anionic surfactants, specifically 4-hexylphenylazosulfonate (Azo) and its sodium derivatives. These surfactants can be rapidly degraded upon UV irradiation, making them highly effective for top-down and bottom-up proteomics. They solubilize proteins and peptide fragments with performance comparable to sodium dodecyl sulfate (SDS) and are compatible with mass spectrometry analysis. His research has demonstrated that using these surfactants allows for the detection of 100-fold more unique proteoforms compared to traditional methods. Additionally, they facilitate the solubilization of membrane proteins, enabling comprehensive characterization of protein post-translational modifications.
Another notable patent focuses on a strategy enabled by a photo-cleavable surfactant for extracellular vesicle proteomics. Exosomes, which are small extracellular vesicles, play a crucial role in tumorigenesis and cardiac regeneration. Brown's invention provides a high-throughput strategy for analyzing exosome proteomics, addressing challenges related to labor-intensive sample preparation and the need for high sensitivity. His photo-cleavable, anionic surfactants streamline the digestion process, allowing for quantitative and highly reproducible analysis.
Career Highlights
Kyle Brown is associated with the Wisconsin Alumni Research Foundation, where he continues to innovate and contribute to scientific advancements. His work has garnered attention for its potential applications in diagnostics and drug delivery.
Collaborations
Some of his notable coworkers include Ying Ge and Song Jin, who have collaborated with him on various projects related to proteomics.
Conclusion
Kyle Brown's innovative contributions to the field of proteomics through his patented surfactants are paving the way for advancements in protein analysis and diagnostics. His work exemplifies the impact of innovation in scientific research and its potential to improve healthcare outcomes.