This inventor holds 1 USPTO granted patent. Top assignee: Jawaharlal Nehru Centre for Advanced Scientific Research. Active years: 2008.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile
Company Filing History:
Years Active: 2008
Title: Kundu Tapas Kumar: Innovator in Histone Acetyltransferase Inhibition
Introduction
Kundu Tapas Kumar is a notable inventor based in Bengaluru, India. He has made significant contributions to the field of biochemistry, particularly in the development of inhibitors for histone acetyltransferases. His work has implications for cancer research and therapeutic development.
Latest Patents
Kundu Tapas Kumar holds a patent titled "Polyisoprenylated benzophenones and their isomers as inhibitors of histone acetyltransferases and uses thereof." This patent describes the purification of prenylated benzophenones from fruit rinds and evaluates their effectiveness as inhibitors for histone acetyltransferases p300 and PCAF. The findings indicate that these compounds are potent HAT inhibitors, with IC values of 1 µM for p300 and 15 µM for pCAF. The inhibitors significantly repress p300 HAT-dependent transcriptional activation from in vitro assembled chromatin templates, while showing no effect on transcription from DNA. These results suggest that the compounds could be specific to HATs, making them useful as biological switching molecules for evaluating the roles of p300 and PCAF in cellular functions. Furthermore, they may serve as new chemical entities for the development of anticancer drugs.
Career Highlights
Kundu Tapas Kumar is affiliated with the Jawaharlal Nehru Centre for Advanced Scientific Research, where he conducts his research. His work has garnered attention for its potential applications in cancer treatment and understanding cellular mechanisms.
Collaborations
Kundu has collaborated with notable colleagues, including Karanam Balasubramanyam and Kempegowda Mantelingu. Their combined expertise enhances the research output and innovation in their field.
Conclusion
Kundu Tapas Kumar's innovative work in developing histone acetyltransferase inhibitors showcases his commitment to advancing cancer research. His contributions are paving the way for new therapeutic strategies in the fight against cancer.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile