This inventor holds 2 USPTO granted patents. Top assignee: University System of Maryland. Active years: 2001.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile
Company Filing History:
Years Active: 2001
Title: Kun Yao: Innovator in Viral Research
Introduction
Kun Yao is a prominent inventor based in College Park, MD (US). He has made significant contributions to the field of virology, particularly in the development of nonpathogenic viruses for research and vaccine development. With a total of 2 patents, his work is paving the way for advancements in viral pathogenesis studies.
Latest Patents
Kun Yao's latest patents include a method for generating nonpathogenic infectious pancreatic necrosis virus (IPNV) from synthetic RNA transcripts. This innovative system allows for the generation of live, nonpathogenic IPNV, a segmented double-stranded RNA virus of the Birnavirdae family. The method involves constructing independent full-length cDNA clones containing the coding and non-coding regions of RNA segments A and B of IPNV. Segment A is modified to prevent the expression of the NS protein, and synthetic RNAs of both segments are produced through in vitro transcription. Transfection of CHSE cells with these transcripts results in the generation of infectious virus, which is crucial for studying viral pathogenesis and developing live attenuated vaccines.
Another significant patent by Kun Yao is a method for generating nonpathogenic infections birnavirus from synthetic RNA transcripts. This system focuses on the infectious bursal disease virus (IBDV), also a segmented double-stranded RNA virus of the Birnavirdae family. Similar to his work with IPNV, independent full-length cDNA clones are constructed, and segment A is modified to prevent NS protein expression. The synthetic RNAs are produced and transfected into Vero cells, generating infectious virus as early as 36 hours post-transfection. This development is vital for studying immunosuppression and advancing live attenuated vaccines for IBDV.
Career Highlights
Kun Yao is affiliated with the University System of Maryland, where he conducts his research and innovation. His work has garnered attention in the scientific community, contributing to the understanding of viral diseases and vaccine development.
Collaborations
Kun Yao collaborates with Vikram N Vakharia, a fellow researcher in the field. Their partnership enhances the research efforts in virology and vaccine development.
Conclusion
Kun Yao's contributions to the field of virology through his innovative patents are significant. His work on nonpathogenic viruses is essential for advancing research
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile