Kun M Shih

Title: Innovations of Kun M Shih in Injectable Compositions

Introduction

Kun M Shih is a notable inventor based in East Syracuse, NY (US). He has made significant contributions to the field of pharmaceuticals, particularly in the development of injectable compositions. With a total of 6 patents to his name, his work has had a considerable impact on medical formulations.

Latest Patents

Shih's latest patents focus on injectable compositions of cefepime dihydrochloride hydrate. These compositions include crystalline sulfuric, di-nitric, mono-hydrochloric, di-hydrochloric, and di- and sesqui-orthosphosphoric acid addition salts of 7-[.alpha.-(2-aminothiazol-4-yl)-.alpha.-(Z)-methoxyiminoacetamido]-3-[(1-methyl-1-pyrrolidinio)methyl]-3-cephem-4-carboxylate, which are stable even at elevated temperatures. The crystalline sulfuric acid addition salt is created by forming an admixture of at least one molar equivalent of sulfuric acid with a zwitterion, leading to crystallization. The process involves separating the crystals, washing, and drying them. Additionally, the crystalline monohydrochloride, dihydrochloride, and orthophosphate salts are prepared by dissolving the zwitterion in the appropriate amount of acid, followed by crystallization through the addition of acetone.

Career Highlights

Throughout his career, Kun M Shih has worked with prominent companies such as Bristol-Myers Company and Bristol-Myers Squibb Company. His expertise in pharmaceutical formulations has been instrumental in advancing injectable drug compositions.

Collaborations

Shih has collaborated with notable colleagues, including Murray A Kaplan and Thomas W Hudyma. Their combined efforts have contributed to the development of innovative pharmaceutical solutions.

Conclusion

Kun M Shih's contributions to the field of injectable compositions demonstrate his commitment to advancing medical science. His innovative patents and collaborations highlight the importance of research and development in pharmaceuticals.